Research
My
main research
interest concerns the analysis of gene expression data obtained from
breast cancer samples. The aim is to identify the key genes
related to the evolution of cancer or the effect of a treatment. The
resulting biological knowledge should allow us to bring new insights
into breast cancer biology and to build new prognostic and predictive
tools to improve the management of patients.
The gene expression profiling generates a huge amount of data and the Machine
Learning methods are
good candidates to analyze such
data. The use of survival analysis coupling to Machine Learning methods
(e.g. feature selection, cross-validation, etc) need
to be studied carefully in
order to adapt the methodology to such problems.
The new methods are tested on original data coming from the Functional
Genomics and Translational Research Unit at the
Institut
Jules Bordet and numerous international collaborations.
Research
Interests
- Gene expression Profiling
- Classification
and Regression
Research Groups
Publications
A list of my publications is also available on my Harvard webpage.
Book Chapter
- Computational Intelligence in
Clinical Oncology : Lessons Learned from an Analysis of a Clinical Study.
Haibe-Kains
B,
Desmedt C, Loi S, Delorenzi M, Sotiriou C, and Bontempi G, volume 122 titled Applications of Computational Intelligence in Bioinformatics and
Biomedicine: Current Trends and Open Problems of Studies in
Computational Intelligence, chapter 10, pages 237-268, Springer-Verlag, 2008. [BibTeX]
Editorial
- Time to move forward from "first generation" prognostic gene signatures in early breast cancer. Desmedt C, Michiels S, Haibe-Kains B, Loi S, Sotiriou C, Editorial in Breast Cancer Research and Treatment, in press, 2010.
- Classification models for breast cancer molecular subtyping: What is the best candidate for a translation into clinic? Haibe-Kains B, Editorial in Women’s Health, in press, September 2010.
International Journal
- Low CD10 mRNA expression identifies high-risk ductal carcinoma in situ (DCIS). Toussaint J, Durbecq V, Altintas S, Doriath V, Rouas G, Paesmans M, Bedard P, Haibe-Kains B, Tjalma WA, Larsimont D, Piccart MJ, Sotiriou C in PLoS ONE, 5(8):e12100, 2010. [PDF]
- Long
term in vitro treatment of human glioblastoma cells with temozolomide
increases resistance in vivo through up-regulation of GLUT transporter
and aldo-keto reductase enzyme AKR1C expression. Le Calvé B, Rynkowski M, LeMercier M, Bruyère C, Lonez C, Gras T, Haibe-Kains B, Bontempi G, Decaestecker C, Ruysschaert JM, Kiss R and Lefranc F in Neoplasia, 12(9):727-739, 2010. [PDF]
- PIK3CA
mutations associated with gene signature of low mTORC1 signaling and
better outcomes in estrogen receptor positive breast cancer. Loi S, Haibe-Kains B,
Majjaj S, Lallemand F, Durbecq V, Larsimont D, Gonzalez-Angulo AM,
Pusztai L, Symmans FW, Bardelli A, Ellis P, Tutt AN, Gillett CE, Mills
GB, Hennessy BT , Phillips WA, Piccart MJ, Speed TP, McArthur GA,
Sotiriou C in PNAS, in press, 2010. [PDF] [BibTeX]
- Evaluation
of an RNA interference screen-derived mitotic and ceramide pathway
meta- gene in paclitaxel-treated primary ER-/PR-/ERBB2- breast cancer:
a retrospective analysis of five clinical trials. Juul N, Eklund AC, Li Q, Burrell RA, Gerlinger M, Valero V, Andreopoulou E, Esteva FJ, Symmans FW, Desmedt C, Haibe-Kains B, Sotiriou C, Pusztai L, Szallasi Z and Swanton C in Lancet Oncology, in press, 2010. [PDF] [BibTeX]
- A fuzzy gene expression-based computational approach improves breast cancer prognostication. Haibe-Kains B*, Desmedt C*, Rothé F, Sotiriou C and Bontempi G in Genome Biology, volume 11, number 2, pages R18, 2010. [PDF] [BibTeX]
- Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. Li Y, Zou L, Li Q, Haibe-Kains B,
Tian R, Li Y, Desmedt C, Sotiriou C, Szallasi Z, Iglehart JD,
Richardson AL, Wang ZC in Nature Medecine, volume 16, number 2, pages
214-218, 2010. [PDF] [BibTeX]
- Long-term
Temozolomide Treatment Induces Marked Amino Metabolism Modifications
and an Increase in TMZ Sensitivity in Hs683 Oligodendroglioma Cells. Lamoral-Theys D, Le Mercier M, le Calve B, Rynkowski MA, Bruyere C, Deacestecker C, Haibe-Kains B, Bontempi G, Dubois J, Lefranc F and Kiss R in Neoplasia, volume 12, number 1, 2010. PDF] [BibTeX]
- Improvement
of the clinical applicability of the Genomic Grade Index through a
qRT-PCR test performed on frozen and formalin-fixed paraffin-embedded
tissues. Toussaint
J, Sieuwerts AM, Haibe-Kains B, Desmedt C, Rouas G, Harris AL,
Larsimont D, Piccart MJ, Foekens JA, Durbecq V and Sotiriou C in BMC Genomics, volume 10, number 424, September 2009. [Abstract] [PDF] [BibTeX]
- The Gene
expression Grade Index: a potential predictor of relapse for
endocrine-treated breast cancer patients in the BIG 1-98 trial. Desmedt C, Giobbie-Hurder 1, Neven P, Paridaens R, Christiaens M, Smeets A, Lallemand F, Haibe-Kains B, Viale G, Gelber RD, Piccart MJ, Sotiriou C in BMC Medical Genomics, volume 2, number 40, July 2009. [Abstract] [PDF] [BibTeX]
- Gene
expression profiling identifies activated growth factor signaling in
poor prognosis (Luminal-B) estrogen receptor positive breast cancer. Loi S, Sotiriou C, Haibe-Kains B, Lallemand F, Conus NM, Piccart MJ, Speed TP, McArthur GA in BMC Medical Genomics, volume 2, number 37, July 2009. [Abstract] [PDF] [BibTeX]
- Molecular
profiling of CD3-CD4+ T cells from patients with the lymphocytic
variant of hypereosinophilic syndrome reveals targeting of growth
control pathways. Ravoet M, Sibille C, Gu C, Libin M, Haibe-Kains B, Sotiriou C, Goldman M, Roufosse F and Willard-Gallo K in Blood, June 2009. [Abstract] [PDF] [BibTeX]
- The Genomic Grade Index (GGI) Is Associated with Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer. Liedtke C, Hatzis C, Symmans WF, Desmedt C, Haibe-Kains B, Valero V, Kuerer H, Hortobagyi, Piccart MJ, Sotiriou C and Pusztai L in Journal of Clinical
Oncology, volume 27, number 19, pages 3185-3191, July 2009. [Abstract] [PDF] [BibTeX]
- Galectin-1
Proangiogenic and Pro-Migratory Effects in the Hs683 Oligodendroglioma
Model Are Partly Mediated Through the Control of BEX2 Expression.
Le Mercier M, Fortin S, Mathieu V, Roland I, Spiegl-Kreinecker S, Haibe-Kains B, Bontempi G, Decaestecker C, Berger W, Lefranc F and Kiss R in Neoplasia, volume 11, number 5, pages 485-496, May 2009. [Abstract] [PDF] [BibTeX]
- Gene
expression profiling reveals differences in microenvironment
interaction between patients with chronic lymphocytic leukemia
expressing high versus low ZAP70 mRNA. Stamatopoulos B, Haibe-Kains B, Equeter C, Meuleman N, Sorée A, De Bruyn C, Hanosset D, Bron D, Martiat P and Lagneaux L in Haematologica, April 2009. [Abstract] [PDF] [BibTeX]
- MicroRNA-29c
and microRNA-223 downregulation has in vivo significance in chronic
lymphocytic leukemia and improves disease risk stratification. Stamatopoulos B, Meuleman N, Haibe-Kains B, Saussoy P, Van Den Neste E, Michaux L, Heimann P, Martiat P, Bron D and Lagneaux L in Blood, volume 113, number 21, pages 5237-5245, May 2009. [Abstract] [PDF] [BibTeX]
- Comparison of Prognostic Gene Expression signatures for Breast Cancer. Haibe-Kains B*, Desmedt C*, Piette F, Buyse M, Cardoso F, van‘t Veer L, Piccart MJ, Bontempi G and Sotiriou C in BMC Genomics, volume 9, number 394, August 2008. [Abstract] [PDF] [BibTeX]
- A
comparative study of survival models for breast cancer prognostication
based on microarray data: does a single gene beat them all? Haibe-Kains B,
Desmedt C, Sotiriou C and Bontempi G in Bioinformatics,
volume 24, number 19,
pages 2200-2208, July 2008. [Abstract] [PDF] [BibTeX]
- Meta-analysis
of Gene-Expression Profiles in Breast Cancer: Toward a Unified
Understanding of Breast Cancer Sub-typing and Prognosis Signatures. Wirapati P, Sotiriou
C, Kunkel S, Farmer P, Pradervand S, Haibe-Kains B,
Desmedt C, Ignatiadis M, Sengstag T, Schutz F, Goldstein DR, Piccart MJ
and Delorenzi M in Breast Cancer
Research, volume 10, number 4, R65, August 2008. [Abstract] [PDF] [BibTeX]
- Biological
processes associated with breast cancer clinical outcome depend on the
molecular subtypes. Desmedt
C*, Haibe-Kains
B*, Wirapati P, Buyse
M, Larsimont D, Bontempi G, Delorenzi M, Piccart
M, and Sotiriou C in Clinical
Cancer Research, volume 14, number 16,
pages 5158-5165, August 2008. [Abstract] [PDF] [BibTeX]
- Predicting
prognosis using molecular profiling in estrogen receptor-positive
breast cancer treated with tamoxifen. Loi S*, Haibe-Kains B*,
Desmedt C, Wirapati P, Lallemand F, Tutt AM, Gillet C, Ellis P, Ryder
K, Reid JF, Daidone MG, Pierotti MA, Berns EMJJ, Jansen MPHM, Foekens
JA, Delorenzi M, Bontempi G, Piccart MJ and Sotiriou C in BMC
Genomics, volume 9, number 239, May 2008. [Abstract] [PDF] [BibTeX]
- Knocking
Down Galectin 1 in Human Hs683 Glioblastoma Cells Impairs Both
Angiogenesis and Endoplasmic Reticulum Stress Responses. Le Mercier M,
Mathieu V, Haibe-Kains B,
Bontempi G, Mijatovic T, Decaestecker C, Kiss R and Lefranc F
in Journal of Neuropathology
& Experimental Neurology, volume 67, number 5,
pages 456-469, May 2008. [Abstract] [PDF] [BibTeX]
- Nucleolus
and c-Myc: potential targets of cardenolide-mediated antitumor activity. Mijatovic T, De Neve
N, Gailly P, Mathieu V, Haibe-Kains
B, Bontempi G, Lapeira J, Decaestecker C, Facchini V and
Kiss R in Molecular Cancer
Therapeutics, volume 7, number 5,
pages 1285-1296, May 2008. [Abstract] [PDF] [BibTeX]
- UNBS5162,
a Novel Naphthalimide That Decreases CXCL Chemokine Expression in
Experimental Prostate Cancers.
Mijatovic T, Mahieu
T, Bruyère C, De Nève N, Dewelle J, Simon G, Dehoux MJM, van der Aar E,
Haibe-Kains
B, Bontempi G, Decaestecker C, Van Quaquebeke E, Darro F
and Kiss R in Neoplasia, volume 10, number 6,
pages 573-586, May 2008. [Abstract] [PDF] [BibTeX]
- Evidence
of galectin-1 involvement in glioma chemoresistance. Le Mercier M, Lefranc
F, Mijatovic T, Debeir O, Haibe-Kains
B, Bontempi G, Decaestecker C, Kiss R and Mathieu
V in Toxicology
and Applied Pharmacology, volume 229, number 2,
pages 172-183, January 2008. [Abstract] [PDF] [BibTeX]
- Quantification
of ZAP70 mRNA in B Cells by Real-Time PCR Is a Powerful Prognostic
Factor in Chronic Lymphocytic Leukemia. Stamatopoulos B,
Meulemans
N, Haibe- Kains B,
Duvillier H, Massy M, Martiat P, Bron D, and Lagneaux L in Clinical
Chemistry, volume 53, number 10, August 2007. [Abstract] [PDF] [BibTeX]
- 4-IBP:
A s1 Receptor Agonist Decreases the Migration of Human Cancer Cells
Including Glioblastoma Cells In Vitro and Sensitizes Them In Vitro and
In Vivo to the Cytotoxic Insults of Pro-Apoptotic and Pro-Autophagic
Drugs. Mégalizzi
V, Mathieu V, Mijatovic T, Gailly P, Debeir O, De Neve N, Van Damme M,
Bontempi G, Haibe-Kains B,
Decaestecker C, Kondo Y, Kiss R and Lefranc
F in Neoplasia, volume 9, number 5,
May 2007. [Abstract] [PDF] [BibTeX]
- Strong
time-dependency of the 76-gene prognostic signature for node-negative
breast cancer patients in the TRANSBIG multi-centre independent
validation series. Desmedt
C, Piette F, Loi S, Wang Y, Lallemand F, Haibe-Kains B, Viale
G,
Delorenzi M, Zhang Y, Saghatchian d’Assignies M, Bergh J, Lidereau R,
Ellis P, Harris A, Klijn JG, Foekens JA, Cardoso F, Piccart M, Buyse M
and Sotiriou C in Clinical Cancer
Research, volume 13, number 11,
pages 3201-3214, June 2007. [Abstract] [PDF] [BibTeX]
- Definition
of clinically distinct molecular subtypes in estrogen receptor positive
breast carcinomas through use of genomic grade. Loi
S*, Haibe-Kains B*, Desmedt
C, Lallemand F, Tutt AM, Gillet C,
Harris A, Bergh J, Foekens JA, Klijn J, Larsimont D, Buyse M Bontempi
G, Delorenszi M, Piccart MJ and Sotiriou C in Journal of Clinical
Oncology, volume 25, number 10, April 2007. [Abstract] [PDF] [BibTeX]
- Gene
expression profiling in
breast cancer: Understanding the molecular basis of histologic grade to
improve prognosis, Sotiriou
C, Wirapati P, Loi S, Harris A, Bergh J, Smeds J, Farmer P, Praz V, Haibe-Kains B,
Lallemand F, Buyse M, Piccart MJ and Delorenzi M in Journal
of National Cancer Institute, volume 98, pages
262-272, February 2006. [Abstract] [PDF] [BibTeX]
- Gene
regulation
by phorbol 12-myristate
13-acetate in MCF-7 and MDA-MB-231, two breast cancer cell lines
exhibiting highly different phenotypes, Lacroix
M, Haibe-Kains B,
Hennuy B, Laes JF, Lallemand F, Gonze I,
Cardoso F, Piccart MJ, Leclercq G and Sotiriou C in Oncology Reports,
volume 12, number 4, pages 701-708, October 2004. [Abstract] [PDF] [BibTeX]
International
Conference
- Correlation
of PIK3CA mutation-associated gene expression signature (PIK3CA-GS)
with deactivation of the PI3K pathway and with prognosis within the
luminal-B ER+ breast cancers. Loi S, Haibe-Kains B, Lallemand F,
Pusztai L, Bardelli A, Gillett C, Ellis P, Piccart-Gebhart MJ, Phillips
WA, McArthur GA and Sotiriou C in American
Society of Clinical
Oncology Meeting, Orlando 2009, poster presentation, 2009. [Abstract] [PDF] [BibTeX]
- MicroRNA-29c
and 223 Are Powerful Prognostic Factors for Chronic Lymphocytic
Leukemia and Improve Risk Stratification When Combined with ZAP70 and
LPL in a qPCR Score. Stamatopoulos B, Meuleman N, Bron D, Haibe-Kains B, Saussoy P, Martiat P and Lagneaux L in the 50th American Society of Hematology (ASH) Meeting, San Francisco, USA, December 2008. [Abstract] [PDF]
- Correlation
of gene expression analysis of tumor-infiltrating CD4+ cells with
immune function and survival according to different breast cancer (BC)
molecular subtypes. Sotiriou C, Equeter C, El Ouriaghli F,
Haibe-Kains
B, Durbecq V, Larsimont D, Igniatiadis M, Desmedt C,
Willard-Gallo K and Piccart MJ in the American
Society of Clinical
Oncology Meeting, abstract #11022. [Abstract] [PDF]
- Farnesoid
X receptor (FXR) status complements the evaluation of estrogen receptor
alpha (ER) in breast cancer (BC) patients and predicts benefit from
tamoxifen. Journe F, Durbecq V, Haibe-Kains B, Chaboteaux C, Rouas G, Laurent G, Larsimont D, Piccart MJ, Body JJ, Sotiriou C in the European Journal of Cancer Supplements, volume 6, number 7, page 112, April 2008. [Abstract] [PDF] [BibTeX]
- Molecular qRT-PCR grade index: a new tool for breast cancer (BC) patient grading improvement. Toussaint J, Sieuwerts A, Durbecq V, Haibe-Kains B, Berns E, Harris AL, Larsimont D, Piccart MJ, Foekens J, Sotiriou C in the European Journal of Cancer Supplements, volume 6, number 7, page 140, April 2008. [Abstract] [PDF] [BibTeX]
- Farnesoid X receptor (FXR): A new marker for the prediction of bone metastases in breast cancer. Journe F, Durbecq V, Chaboteaux C, Rouas G, Haibe-Kains B, IdBoufker H, Laurent G, Sotiriou C, Larsimont D and Body J in the Cancer Treatment Reviews, 2008. [Abstract] [PDF] [BibTeX]
- CLL
patient comparison according to Zap70 mRNA level: new prognostic
factors, differences in microRNA expression and distinct interaction
capacities with the microenvironment. Stamatopoulos B, Haibe-Kains B,
Meuleman N, Bron D, Martiat P and Lagneaux L In the
Proceedings of the 13th Congress of the
European Hematology Association (EHA), Copenhagen, Denmark,
2008. [Abstract] [PDF]
- The nucleolus, a potential
target of cardenolide-mediated anti-tumor activity.
Mijatovic T, De Neve N, Gailly P, Mathieu V, Haibe-Kains B,
Bontempi
G, Decaestecker C, Facchini V, Kiss R. In the Proceedings of
the Belgium
society for cell and developmental biology autumn meeting,
Louvain-la-neuve, 2007, abstract #46. [Abstract]
- ORP150, a major target of
Galectin-1 pro-angiogenic effects in human Hs683 glioblastoma xenografts.
Lefranc F, Le Mercier M, Mathieu V, Haibe-Kains
B, Bontempi G, Mijatovic T, Decaestecker C, Kiss R. In the
Proceedings of the Belgium society for cell and developmental
biology autumn meeting, Louvain-la-neuve, 2007, abstract #31. [Abstract] [PDF]
- Galectin-1 regulates P53 and is
implicated in glioma cell resistance to cytotoxic drugs. Le
Mercier M, Lefranc F, Mijatovic T, Debeir O, Haibe-Kains B, Bontempi
G, Decaestecker C, Kiss R, Mathieu V. In the
Proceedings of the Belgium society for cell and developmental
biology autumn meeting, Louvain-la-neuve, 2007, abstract #33. [Abstract] [PDF]
- Interactions
between breast cancer cells and their stromal component: an analysis of
alterations in gene expression. Sotiriou
C, El Ouriaghli F, Majjaj S, Haibe-Kains B, Desmedt
C, Lallemand F, Larsimont D, Piccart MJ in San
Antonio Breast
Cancer Symposium 2007, poster #3092, San Antonio,
Texas, USA. [Abstract] [PDF]
- Meta-analysis
of gene-expression profiles in breast cancer: towards a unified
understanding of breast cancer sub-typing and prognosis signatures. Sotiriou
C, Wirapati P, Kunkel S, Farmer
P, Pradervand S, Haibe-Kains B, Desmedt
C, Sengstag T, Schütz F, Goldstein
DR, Delorenzi M, Piccart MJ in Breast Cancer Research and Treatment, volume 106,
supplement 1, pages S56-S7, 2007. [Abstract] [PDF]
- Chronic Lymphocytic Leukemia:
which prognostic factor to choose?.Stamatopoulos B,
Meuleman N, Haibe-Kains B,
Duvillier H, Massy M, Martiat P, Bron D,
Lagneaux L. Poster presented at the 12th
International Workshop on Chronic Lymphocytic Leukemia (iwCLL), London, 14-16
September, 2007. [Abstract] [PDF]
- Gene expression profiling
identifies potential therapeutic targets in estrogen receptor positive
breast cancer. Loi S, Haibe-Kains B,
Sotiriou C, Lallemand F, Piccart MJ, Campbell
I, Wayne P and McArthur GA in the American
Society of Clinical
Oncology Meeting, San Francisco 2007, poster, 2007. [Abstract] [PDF]
- A poor prognosis gene
transcription signature associated with PIK3CA mutation in ER+ breast
cancer. Loi S, Haibe-Kains B,
Sotiriou C, Lallemand F, Piccart MJ, Wayne P and McArthur GA in the San
Antonio Breast
Cancer Symposium 2006, oral
presentation #26
published in Breast Cancer Research and Treatment, supplement 1, volume
100, page S86, 2007. [Abstract] [PDF]
- Gene
expression comparison between B cells expressing high and low level of
Zap-70 mRNA reveals distinct profiles, potential therapeutic targets
and new prognostic factors for Chronic Lymphocytic Leukemia. Stamatopoulos B,
Equeter C, Haibe-Kains B,
Soree A, Sotiriou C, Bron D, Martiat P, Lagneaux L in the 12th
Congress of the European Hematology Association, Neue Messe
Vienna, Austria, June 7 - 10, 2007, abstract #0513. [Abstract] [PDF]
- Zap-70
mRNA expression quantified in B cell by real time PCR is a powerful
prognostic factor in Chronic Lymphocytic Leukemia. Stamatopoulos B,
Meuleman N, Haibe-Kains B,
Duvillier H, Massy M, Martiat P, Bron D,
Lagneaux L in the 12th
Congress of the European Hematology Association, abstract #0111, Neue Messe
Vienna, Austria, June 7 - 10, 2007. [Abstract] [PDF]
- Identification of potential
therapeutic targets in estrogen receptor-positive breast cancer by gene
expression profiling. Loi S, Haibe-Kains B, Phillips
WA, Lallemand F, Campbell IG, Piccart
MJ, Sotiriou C and McArthur GA in the American
Society of Clinical
Oncology Meeting,
abstract #26, Chicago, 2007. [Abstract]
- Investigating
tamoxifen resistance in the luminal B estrogen receptor positive breast
cancer subtype: Tailoring treatment in hormone responsive breast cancer. Loi S, Sotiriou C, Haibe-Kains B,
Lallemand F, Conus N, Piccart MJ, Speed T and McArthur GA. in the Proceedings
of the American
Society of Clinical
Oncology Meeting, abstract #10603, Chicago 2007. [Abstract] [PDF]
- Biological
mechanisms that trigger breast cancer (BC) tumor progresion are
molecular subtype dependent. Sotiriou C, Desmedt C, Haibe-Kains B, Harris A, Larsimont
D, Buyse M, Wirapati P, Delorenzi M, Bontempi
G and Piccart
MJ in the Proceedings
of the American
Society of Clinical
Oncology Meeting, abstract #10581, Chicago 2007. [Abstract] [PDF]
- Gene
expression profiling can predict pathological complete response (pCR)
to anthracycline-based therapy in estrogen-receptor (ER) negative
breast cancer (BC) patients. Desmedt C, Andre F,
Azambuja E, Haibe-Kains B,
Larsimont D, D’Hondt V, Di Leo A, Piccart
MJ, Pusztai L and Sotiriou C in the Proceedings
of the American
Society of Clinical
Oncology Meeting, Chicago 2007, abstract #10564. [Abstract] [PDF]
- Transforming
genomic grade index (GGI) into a user-friendly qRT-PCR tool which will
assist clinicians and patients in optimizing treatment of early breast
cancer (BC). Durbecq V, Toussaint
J, Haibe-Kains B,
Desmedt C, Rouas G, Larsimont D, Buyse M, Bontempi G,
Piccart MJ and Sotiriou C in the Proceedings
of the American
Society of Clinical
Oncology Meeting, Chicago 2007, abstract #21058. [Abstract]
- CD4+ T cells
infiltrating breast tumors exhibit altered expression
of T cell immune response genes in comparison with their counterparts
from the lymph node and blood. Equeter C, El Ouriaghli
F, Haibe-Kains B, Stamatopoulos
B, André
F, Lallemand F, Filippov
V, Larsimont D, Sotiriou C and Willard-Gallo K. in the Fourth International Conference on Tumor
Microenvironment (AACR), Florence, 2006. [Abstract] [PDF]
- Comprehensive molecular analysis
of
several prognostic signatures using molecular indices related to
hallmarks of breast cancer: proliferation index appears to be the most
significant component of all signatures. Sotiriou
C, Haibe-Kains B, Desmedt
C, Wirapati
P, Durbecq
V, Harris A, Larsimont D, Bontempi
G, Buyse
M, Delorenzi M and Piccart MJ. in the San
Antonio Breast
Cancer Symposium 2006, poster #2020
published in Breast Cancer Research and Treatment, supplement 1, volume
100, page S86, 2006. [Abstract] [PDF]
- Gene expression profiling can
predict
pathological complete response (pCR) to anthracycline-monotherapy in
estrogen-receptor (ER) negative breast cancer (BC) patients. Desmedt
C, Azambuja E, Di Leo A, Larsimont D, Durbecq V, Antoine D, Lallemand
F, Haibe-Kains B,
Cardoso F, Nogaret JM, Fontaine D, Liebens F, Duhem
C, Kains JP, Maerevoet M, Richard V, Vindevoghel A, Delaloge S, Buyse
M, D’Hondt V, Piccart MJ and Sotiriou C. in the San
Antonio Breast
Cancer Symposium 2006, poster #3022
published in Breast Cancer
Research and Treatment, supplement 1, volume 100, page S131, 2006. [Abstract] [PDF]
- Decreasing Galectin-1 Expression
in Human Hs683 Glioblastoma Cells Impairs their Response to Endoplasmic
Reticulum Stress.
Le Mercier M, Camby I, Mathieu V, Dumont P, De Neve N, Roland I, Haibe-Kains B,
Bontempi G, Mijatovic T, Kondo Y, Decaestecker C, Kiss R
and Lefranc F. In the Proceedings of the Belgium
society for cell and developmental biology autumn meeting,
Gent, 2006, abstract #23. [Abstract] [PDF]
- Comprehensive
analysis integrating both clinicopathological and gene expression data
in more than 1500 samples: Proliferation captured by gene expression
grade index appears to be the strongest prognostic factor in breast
cancer (BC). Sotiriou C,
Wirapati P, Loi S, Haibe-Kains B, Desmedt
C, Tutt A., Ellis P., Buyse M, Delorenzi M and
Piccart
MJ in the American Society of Clinical
Oncology, oral
presentation, abstract #507, Atlanta 2006. [Abstract] [PDF] [BibTeX]
- TRANSBIG
multi-centre independent validation of the Rotterdam 76-gene prognostic
signature for patients with node-negative breast cancer. Desmedt C,
Piette F, Cardoso
F, Y. Wang, Loi S, Lallemand F, Klijn J, Haibe-Kains B, Viale
G,
Delorenzi M, Zhang Y, Saghatchian d'Assignies M, Bergh J, Lidereau R,
Ellis P, Harris A, Foekens J, Buyse M, Piccart
MJ and Sotiriou C in the European
Breast Cancer Conference 2006, presidential
session. [Abstract] [PDF]
- Is genomic grading killing
histological grading ? Sotiriou C, Wirapati P, Loi S,
Desmedt C, Haibe-Kains B,
Piette F, Buyse M, Bontempi G, Delorenzi M,
Piccart MJ, in the European
Breast Cancer Conference 2006, presidential
session, published in European Journal of Cancer Supplements, volume 4, number 2, page 177. [Abstract] [PDF]
- Better characterization of
estrogen receptor (ER) positive luminal subtypes using genomic grade.
Sotiriou C,
Wirapati P, Loi S, Desmedt C, Durbecq V, Harris A, Bergh J, Smeds J, Haibe-Kains B,
Larsimont D, Cardoso F, Buyse M, Delorenzi M and Piccart
MJ in the San
Antonio Breast
Cancer Symposium 2005, general session
#37 published in Breast
Cancer Research and Treatment, volume 94, supplement 1, page S19, 2005. [Abstract] [PDF]
- Four genes by RT-PCR predicts
distant relapse for women given adjuvant tamoxifen.
Desmedt C, Loi S, Haibe-Kains
B, Soree A, Lallemand F, Durbecq V,
Larsimont D, Tutt A, Ellis P, Gillett C, Ryder K, Harris A, Cardoso F,
Martiat PH, Piccart MJ and Sotiriou C in the San
Antonio Breast
Cancer Symposium 2005, poster session #3025 published in Breast
Cancer Research and Treatment, volume 94, supplement 1, page S133, 2005. [Abstract] [PDF]
- Predicting relapse in estrogen
receptor (ER) positive breast cancer (luminal) subgroups treated with
adjuvant tamoxifen. Loi S,
Desmedt C, Haibe-Kains B,
Lallemand F, Gillett C, Tutt A, Ryder K,
Ellis P, Harris A, Smeds J, Bergh J, Cardoso F, Piccart MJ, Sotiriou
C. in the San
Antonio Breast
Cancer Symposium 2005, poster session
#3016 published in Breast
Cancer Research and Treatment, volume 94, supplement 1, page S129, 2005. [Abstract] [PDF]
- Breast
tumours with intermediate histological grade can be reclassified into
prognostically distinct groups by gene expression profiling.
Sotiriou C,
Wirapati P, Loi S, Viale G, Harris A, Bergh J, Smeds J, Farmer P, Praz
V, Haibe-Kains B,
Lallemand F, Desmedt C, Durbecq V, Larsimont D,
Cardoso F, Buyse M, Delorenzi M and Piccart MJ in the San
Antonio Breast
Cancer Symposium 2005, poster
discussion #302 published in Breast
Cancer Research and Treatment, volume 94, supplement 1, page S30, 2005. [Abstract] [PDF]
- Prediction
of early distant relapses on tamoxifen in early-stage
breast cancer (BC): a potential tool for adjuvant aromatase inhibitor
(AI) tailoring. Loi
S, Piccart MJ, Haibe-Kains
B, Desmedt C, Harris A, Bergh J, Ellis P,
Miller L, Liu E and
Sotiriou C in the Proceedings of the American
Society of Clinical
Oncology Meeting, Orlando 2005, abstract #509. [Abstract] [PDF] [BibTeX]
- Gene expression profiling in
breast cancer challenges the existence of intermediate histological
grade.
Sotiriou C, Wirapati P, Loi S, Harris A, Bergh J, Smeds J, Praz V,
Farmer P, Haibe-Kains B,
Lallemand F, Buyse M, Piccart MJ and Delorenzi
M
presented at the Fifth International Meeting on Statistical Methods in
Biopharmacy, Paris, France, September 26-27, 2005. [Abstract]
- Gene
expression profiling in
breast cancer challenges the existence of the intermediate histological
grade. Sotiriou
C, Wirapati P, Loi S, Harris A, Bergh J, Smeds J, Farmer P, Praz V, Haibe-Kains B,
Lallemand F, Buyse M, Piccart MJ and Delorenzi M in
the Third
International Symposium on the Molecular Biology of Breast Cancer
Molde, Norway. Published in Breast
Cancer Research, volume 7, supplement 2, page 4.33,
2005. [Abstract]
[PDF]
- Potential importance of
PKC-alpha activity in defining breast tumor luminal/basal phenotype.
Lacroix M, Haibe-Kains B,
Laes JF, Hennuy B, Cardoso F, Lallemand F,
Gonze I, Leclercq G, Piccart MJ and Sotiriou C in the San
Antonio Breast
Cancer Symposium 2003, poster session
#671. [Abstract]
[PDF]
National Conference
- Microrna-29c
and microrna-223 downregulation has in vivo significance in chronic
lymphocytic leukemia and improves disease risk stratification. Stamatopoulos B, Meuleman N, Haibe-Kains B, Saussoy P, Van Den Neste E, Michaux L, Heimann P, Martiat P, Bron D, Lagneaux L in the Belgian
Hematology Society (BHS) Annual General Meeting 2009, 30th of January 2008, Oostende, Belgium. [Abstract]
- Identification of Breast Cancer Molecular Subtypes. Haibe-Kains B in the Televie 2007
seminar, 26th November 2008, Liege,
Belgium. [Abstract] [PDF] [BibTex]
- Comparison
of chronic lymphocytic leukemia patients expressing high or low level
of ZAP70 mRNA: new prognostic factors differences in microRNA
expression and interaction with the microenvironment. Stamatopoulos B, Haibe-Kains B,
Equeter C, Debruyn C, Meuleman M, Hanosset D, Sorree A, Bron D, Martiat
M, Lagneaux L in the Belgian
Hematology Society (BHS) Annual General Meeting 2008
25th of January 2008, Oostende, Belgium. [Abstract] [PPT]
- Comparison
of Prognostic Gene Expression signatures for Breast Cancer. Haibe-Kains B,
C. Desmedt, G. Bontempi and Sotiriou C in the Televie 2007
seminar, 5th December 2007,
Brussels,
Belgium. [Abstract] [PDF]
- Comprehensive
analysis integrating both clinico-pathological and gene expression data
in more than 1500 samples: Proliferation captured by gene expression
grade index appears to be thestrongest prognostic factor in breast
cancerene Expression Analaysis of Tamoxifen Resistance in Breast Cancer. Desmedt C, Haibe-Kains B,
and Sotiriou C in the Televie 2006
seminar, 6th of December 2006,
Brussels,
Belgium. [PDF]
- Gene
Expression Analaysis of Tamoxifen Resistance in Breast Cancer. Haibe-Kains B, Loi
S, Desmedt
C, Lallemand
F, Tutt
AM, Gillet C, Ellis P, Ryder K, Harris
A, Bergh
J, Larsimont D, Buyse M, Bontempi
G, Piccart MJ
and Sotiriou C in Computational
Learning and Intelligence,
research Contact Day, 25th of September 2006,
Brussels,
Belgium. [PDF]
Workshops
- Class
Discovery and Class Prediction from Human Cancer Microarray Datasets.
Haibe-Kains
B, Sotiriou C and Bontempi
G in OECI course program about
Microarray Data Generation and Analysis, 28th February 2006,
Brussels,
Belgium. [PDF]
Invited Talks
- Introduction
to MiroArrays and Gene-Expression Profiling and
Statistical analyis of MicroArray Data. Haibe-Kains
B, Sotiriou C and Bontempi G in IDDI
(International Drug Development Institute) meeting, 23th of March 2007,
Louvain-La-Neuve,
Belgium. [PDF] [PDF]
- Gene
Expression Analysis : Tamoxifen Resistance in Breast Cancer. Haibe-Kains B, Loi
S, Desmedt C, Lallemand F, Tutt
AM, Gillet C, Ellis P, Ryder K, Harris
A, Bergh
J, Larsimont D, Buyse M, Bontempi
G, Piccart MJ
and Sotiriou C in CINBIOS (centre de
BioInformatique et BioModelisation) meeting, 29th of September 2006,
Brussels,
Belgium. [PDF]
Thesis
- Identification and Assesment of Gene Signatures in Human Breast Cancer [PDF] [BibTeX]
- PhD Thesis in Bioinformatics at the
Universite Libre de Bruxelles
under the supervision of Prof. Gianluca
Bontempi and Prof. Christos
Sotiriou,
Belgium, April 2009.
- Use
of Machine Learning in Bioinformatics to Identify Prognosis and
Predictive Molecular Signatures in Human Breast
Cancer [PDF] [BibTeX]
- Master
Thesis in Sciences at the
Universite Libre de Bruxelles
under the supervision of Prof. Gianluca
Bontempi and Prof. Christos
Sotiriou,
Belgium, June 2005.
- The
summary and the presentation are
given
here.
- Master
Thesis in Bioinformatics at the
Universite Libre de Bruxelles
under the supervision of Prof. Gianluca
Bontempi and Prof. Christos
Sotiriou, Belgium, July 2004.
- The summary and
the presentation are given here.
- Apprentissage
d'une tache de
controle pour un robot mobile en LEGO Mindstorms [PDF] [BibTeX]
- Thesis
in Computer Science at the
Universite Libre de Bruxelles
under the supervision of Prof. Gianluca
Bontempi,
Belgium, September 2003.
- The
summary and the presentation are given here.
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